Gestational and Postpartum Complications in Patients with First Trimester Thyrotoxicosis: A Prospective Multicenter Cohort Study from Northeast China
Authors' conclusion
In conclusion, pregnancy outcomes appear variable, according to the etiology of first trimester thyrotoxicosis. GTT appears to be associated with GDM. GD appears to be associated with an increased risk of premature delivery, gestational hypertension, and miscarriage.
Study context
- Population
- Pregnant women with first trimester thyrotoxicosis (gestational transient thyrotoxicosis (GTT) or Graves' disease (GD)) and age-matched pregnant women with normal thyroid function, Northeast China; followed until delivery125 thyrotoxicosis, 246 normal thyroid function (NTF)
- Participants
- 78 / 26 / 21 / 246
- Exposure
- GTT vs GD vs normal thyroid function
- GTTn = 78
- GD untreatedn = 26
- GD treatedn = 21
- NTFn = 246reference
- Outcome
- Pregnancy outcomes
- Follow-up
- Until delivery
Methodological detailsmulticenter, age-matched controls
- Multicenter
- Age-matched controls
Main finding
As reported in the abstract
- Thyroid function of GTT returned to normal range in the third trimester, but was consistently abnormal in GD
Observational data: associations, not effects.
Further findings
| Outcome | GTT | GD untreated | GD treated | NTF | P value |
|---|---|---|---|---|---|
| GDMGTT vs NTF · significantly higher with GTT | 11.5% | — not stated in the abstract | — not stated in the abstract | 4.9% | P = 0.037 |
| Premature deliveryGD untreated vs NTF · higher with GD untreated | — not stated in the abstract | 30.8% | 28.6% | 7.7% | P = 0.002 |
| Premature deliveryGD treated vs NTF · higher with GD treated | P = 0.008 | ||||
| MiscarriageGD untreated vs NTF · more prevalent with GD untreated | — not stated in the abstract | 15.4% | — not stated in the abstract | 3.7% | P = 0.026 |
| Gestational hypertensionGD untreated vs NTF · more prevalent with GD untreated | — not stated in the abstract | 19.2% | — not stated in the abstract | 3.3% | P = 0.004 |
— not stated in the abstract
Risk factors: positive TSH receptor antibody (TRAb) for miscarriage; positive thyroid peroxidase antibody (TPOAb) for low birth weight · first trimester antibodies
- Positive TRAb, independent risk factor for miscarriage: OR (CI 1.11-24.78), p = 0.037
- 5.23
- Positive TPOAb, independent risk factor for low birth weight: OR (CI 1.23-48.86), p = 0.029
- 7.76
Original publication
Gestational and Postpartum Complications in Patients with First Trimester Thyrotoxicosis: A Prospective Multicenter Cohort Study from Northeast China. Thyroid. Published 8 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →