Effect of the FetalTHRBGenotype on the Placenta
Authors' conclusion
We present the first study of the effect of the fetal THRB genotype on the placenta. Though limited by virtue of the rarity of THRB mutations and sample availability, we show that the fetal THRB genotype influences the levels of TH regulators in the placenta.
Study context
- Population
- Placentas from 2 term pregnancies of the same woman with thyroid hormone receptor beta (THRB) mutation G307D, plus 2 placentas from healthy women of similar gestational age
- Comparison
- Placenta of THRB-mutation-affected fetus vs placenta of normal fetus
- Outcome
- Placental TH regulators: deiodinase 2 and 3 activity and TH transporter and receptor expression
- Follow-up
- Term delivery
Methodological detailsFetal origin of placental tissue established by gDNA quantitation of X and Y chromosome genes and THRB gene
- Fetal origin of placental tissue established by gDNA quantitation of X and Y chromosome genes and THRB gene
Main finding
As reported in the abstract
- Significant reduction of deiodinase 2 and 3 activities in the affected fetus (AfFe) placenta
- Significant reduction of expression of thyroid hormone (TH) transporters MCT10, LAT1 and LAT2, and of THRA, in the AfFe placenta
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of the FetalTHRBGenotype on the Placenta. J Clin Endocrinol Metab. Published 7 May 2023. doi:10.
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