Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across body mass index (BMI) categories
Authors' conclusion
These findings underscore the genetic influence of central adiposity on SBP regulation, particularly among females with normal weight and overweight. The TG/HDL-C ratio plays a key role in modulating this relationship, suggesting that metabolic risk-targeted interventions may enhance hypertension prevention and management in genetically susceptible populations.
Study context
- Population
- Females from the Taiwan Biobank
- Participants
- 10,734 females
- Exposure
- Normal weight vs Overweight vs Obesity
- Outcome
- Association of PGS of BMI, waist circumference, WHR and waist-to-height ratio with SBP across BMI categories
Methodological detailsTaiwan Biobank, multivariable generalized additive models
- Taiwan Biobank
- Multivariable generalized additive models
Main finding
As reported in the abstract
β
0.026
95% CI 0.002–0.050; p_linear = 0.033
Normal weight · edf = 1.063; F = 3.201; p_smooth = 0.060
β
−0.058
95% CI −0.095 to −0.021; p_linear = 0.002
Overweight · edf = 2.272; F = 4.073; p_smooth = 0.006
Observational data: associations, not effects.
Further findings
Modulation by TG/HDL-C ratio
- TG/HDL-C ratio significantly modulated the PGS-WC–systolic blood pressure (SBP) association across normal weight, overweight and obesity in interaction and mediation analyses
Polygenic pathway analysis
- Implicated signal transduction, metabolism, immune regulation and DNA repair
Original publication
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