Correlation Between Impaired Sensitivity to Thyroid Hormones and Serum Uric Acid in Female Patients With Obesity and After Laparoscopic Sleeve Gastrectomy
Authors' conclusion
Female hyperuricemia is correlated with higher thyroid hormone resistance index scores. Resistance to thyroid hormones was greatly improved by LSG. The decrease in UA levels after surgery is correlated with the improvement of thyroid hormone resistance after LSG.
Study context
- Population
- Euthyroid patients with obesity (481 males, 573 females); 248 (143 female) underwent subsequent laparoscopic sleeve gastrectomy (LSG)248 underwent LSG
- Participants
- 1,054 patients
- Exposure
- Fourth vs first quartile of thyroid hormone sensitivity indices
- Outcome
- Association between impaired thyroid hormone sensitivity and elevated UA levels before and after LSG
- Follow-up
- Before and 3 months after LSG
Main finding
As reported in the abstract
Hyperuricemia in female patients with obesity
Each group vs first quartileEstimate (CI)P value
Fourth quartile
OR (thyroid feedback quantile index) 4.285(1.360–13.507)
all P < .05Fourth quartile
OR (thyrotropin index) 3.700(1.276–10.729)
all P < .05Fourth quartile
OR (thyrotropin-thyroxine resistance index) 2.839(1.014–7.948)
all P < .05- Female patients with obesity with impaired sensitivity to thyroid hormones had higher uric acid (UA) levels
- P for trend < 0.01
Observational data: associations, not effects.
Further findings
Decline in UA after LSG · 3 months after LSG
- Only a positive correlation between UA decline and thyroid feedback quantile index, thyrotropin and thyrotropin-thyroxine resistance index in female patients after LSG
Original publication
Correlation Between Impaired Sensitivity to Thyroid Hormones and Serum Uric Acid in Female Patients With Obesity and After Laparoscopic Sleeve Gastrectomy. Endocr Pract. Published 11 March 2024. doi:10.
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