Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis
Authors' conclusion
We have identified genes whose expression is significantly associated with obesity in a multi-ethnic cohort. We have identified novel genes associated with BMI as well as confirmed previously identified genes from earlier genetic analyses. These novel genes and their biological pathways represent new targets for understanding the biology of obesity as well as new therapeutic intervention to reduce obesity and improve global public health.
Study context
- Population
- Multi-Ethnic Study of Atherosclerosis (MESA) participants in four self-identified race and ethnicity groups (37.8% white, 24.3% Hispanic, 28.4% African American, 9.5% Chinese American)
- Participants
- 1,096 participants
- Outcome
- Association of gene expression with BMI
Methodological detailsmulti-ethnic cohort, RNA-sequencing, sample-size-weighted meta-analysis across ancestry groups
- Multi-ethnic cohort
- RNA-sequencing
- Sample-size-weighted meta-analysis across ancestry groups
Main finding
As reported in the abstract
Genes whose expression is significantly associated with BMI
- Genes significantly (p < 1.97 × 10-6) associated with body mass index (BMI) within individual self-identified race and ethnicity (SIRE) groups
- zero to three
- Genes significantly associated with BMI by meta-analysis across all groups
- 45
- BMI variation explained by the 45 genes
- 29.7%
Observational data: associations, not effects.
Original publication
Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis. Int J Obes (Lond). Published 3 December 2022. doi:10.
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