Association of short-term and long-term weight loss with the risk of major adverse cardiovascular disease: Community-based cohort study
Main finding · MACE, 4-year BMI trajectory modelResult — go to the resultHazard ratio 1.41 95 % CI 1.06–1.91Authors' conclusion
The initial 4-year weight loss was paradoxically associated with a higher risk of MACEs, probably due to residual cardiovascular burden. However, this association became null in participants with sustained weight loss ≥ 6 years, suggesting a possible lag effect of weight loss on MACEs.
Study context
- Population
- Korean middle-aged adults, Korean Genome and Epidemiology Study, enrolled 2001–2002, followed until 2014; median (IQR) age 50 (44–59) years
- Participants
- 6,855 adults
- Exposure
- Decreasing vs stable BMI trajectory
- Outcome
- Occurrence of MACE
- Follow-up
- Mean 10.2 years
Methodological detailsgroup-based trajectory modelling
- Group-based trajectory modelling
Main finding
MACE, 4-year BMI trajectory model
Hazard ratio
1.41
95 % CI 1.06–1.91
Decreasing BMIvs Stable BMI
HR 1.41 (95 % CI 1.06–1.91)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95 % CI) | |
|---|---|---|
| MACE, 6-year BMI trajectory modelDecreasing BMIvs Stable BMISecondary analysis | 1.14 (0.81–1.61) | |
| MACE, 8-year BMI trajectory modelDecreasing BMIvs Stable BMISecondary analysis | 0.98 (0.65–1.49) | |
| 0.512Hazard ratio (log scale) |
Major adverse cardiovascular event (MACE) overall incidence · mean 10.2 years
- MACEs occurred
- 350 (5.1 %)
Cardiometabolic risk factors
- Concomitant improvements in cardiometabolic risk factors in decreasing BMI group, but unfavorable risk burden remained up to 4 to 6 years
Original publication
Association of short-term and long-term weight loss with the risk of major adverse cardiovascular disease: Community-based cohort study. Diabetes Res Clin Pract. Published 1 December 2022. doi:10.
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