Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia
Authors' conclusion
Gastric emptying is slower in women than men with T2D, associated with a reduced blood volume-adjusted glycaemic response to oral glucose and a mixed meal in women. These observations highlight the sex difference in postprandial glucose handling, which is relevant to the personalized management of postprandial glycaemia in T2D.
Study context
- Population
- Cohort 1: 70 newly diagnosed, treatment-naïve Chinese patients with T2D (44 men), 75-g glucose drink; cohort 2: 101 Australian patients with T2D (67 male) on diet and/or metformin, semi-solid mashed potato mealtwo cohorts: 70 and 101
- Exposure
- Women vs men with T2D
- Outcome
- Gastric emptying (breath test) and glycaemic response to a glucose drink and a high carbohydrate meal
- Follow-up
- 3 and 4 h
Methodological detailstwo cohorts
- Two cohorts
Main finding
As reported in the abstract
Gastric emptying
- Gastric emptying was slower in female than male subjects in both cohorts
- Gastric emptying independently associated with sex on multiple linear regression (both p < .05)
- Women vs Men: both p < .01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Glycaemic response to oral glucose and mixed meal, unadjusted for blood volumeGreater in women | both p < .001 |
| Glycaemic response to oral glucose and mixed meal, adjusted for blood volumeGreater in men | both p < .05 |
Original publication
Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia. Diabetes Obes Metab. Published 2 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →