Dose-related effects of intraduodenal quinine on plasma glucose, glucoregulatory hormones and gastric emptying of a nutrient drink, and energy intake, in men with type 2 diabetes: a double-blind, randomised, crossover study
Primary result · Peak plasma glucose after nutrient drink (part A)Result — go to the resultReduction in peak plasma glucose 2.8±0.6 mmol/lAuthors' conclusion
In type 2 diabetes, acute intraduodenal administration of quinine markedly reduces the plasma glucose response to oral carbohydrate, but does not affect energy intake. These findings support the potential use of quinine to reduce postprandial blood glucose levels in type 2 diabetes.
Study context
- Population
- Men with T2D (age 68±5 years; HbA1c 49.0±5.0 mmol/mol [6.7±0.4%]; BMI 30±1 kg/m²)parts A and B, n=12 each
- Comparison
- Intraduodenal quinine hydrochloride 300 mg or 600 mg vs control
Methodological detailsdouble-blind, two study parts (A and B)
- Double-blind
- Two study parts (A and B)
Primary result
As reported in the abstract
Peak plasma glucose after nutrient drink (part A)
Reduction in peak plasma glucose
2.8±0.6 mmol/l
P < 0.05
Further findings
Gastric emptying of nutrient drink (13C-acetate breath test)
- Both quinine doses slowed gastric emptying (p<0.05)
- n=11
Plasma GLP-1 and C-peptide
- QHCl-600, but not QHCl-300, stimulated plasma GLP-1 and C-peptide modestly (both p<0.05)
Quinine alone (before drink) · 30 min after quinine
- Quinine alone had no effect
Energy intake at buffet-lunch (part B)
- Quinine did not affect energy intake
Original publication
Dose-related effects of intraduodenal quinine on plasma glucose, glucoregulatory hormones and gastric emptying of a nutrient drink, and energy intake, in men with type 2 diabetes: a double-blind, randomised, crossover study. Diabetologia. Published 18 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →