Type 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers
Primary result · Incident T2DResult — go to the resultHazard ratio 1.43 95% CI 1.20–1.70Authors' conclusion
The T2D polygenic score serves as an independent predictor of incident diabetes, particularly among individuals with lower distribution of traditional risk factors.
Study context
- Population
- Participants with stable atherosclerotic CVD and LDL-C ≥70 mg/dL (1.8 mmol/L) on statin therapy in the FOURIER trial (evolocumab vs placebo); mean age 63 ± 9 years, 22.7% women
- Participants
- 9,388 participants
- Comparison
- High vs low to intermediate T2D genetic risk
- Primary endpoint
- Incident diabetes (centrally adjudicated)
- Follow-up
- 2.3 years of median
Primary result
Incident T2D · 2.3 years median follow-up
Hazard ratio
1.43
95% CI 1.20–1.70
P < 0.001
By group
Highvs Low to intermediate
HR 1.43 (95% CI 1.20–1.70); P < 0.001
As reported in the abstract
- T2D polygenic score (PGS) predicted incident T2D
- HR per 1-SD 1.22 (95% CI 1.14-1.32, p < 0.001)
- Diabetes developed overall
- 690 participants (7.3%)
Further findings
Interaction of high T2D genetic risk with HbA1c and body mass index (BMI)
- Greater predictive strength among individuals with lower HbA1c (P-int)
- 0.0499
- Greater predictive strength among individuals with lower BMI (P-int)
- 0.004
Original publication
Type 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers. Diabetes Obes Metab. Published 18 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →