Long‐term weight loss and cardiorenal outcomes by baseline body mass index (BMI) in the VERTIS cardiovascular (CV) trial
Authors' conclusion
Weight loss was observed across baseline BMI and was sustained over 5 years of follow-up. The effects of ertugliflozin on HHF and kidney composite were consistent across baseline BMI.
Study context
- Population
- Patients with T2D and atherosclerotic CVD; mean age 64.4 years, diabetes duration 13.0 years, BMI 32.0 kg/m², 61% with BMI >30 kg/m²
- Participants
- 8,246 patients
- Comparison
- Ertugliflozin vs placebo by baseline BMI
- Primary endpoint
- Weight loss and cardiorenal outcomes (CV death or HHF composite, CV death, HHF, exploratory kidney composite incl. ≥40% eGFR decrease) by baseline BMI
Methodological detailspost hoc analysis, subgroups by baseline BMI
- Post hoc analysis
- Subgroups by baseline BMI
Primary result
As reported in the abstract
- Absolute body weight reduction greater with ertugliflozin vs placebo at 3 and 5 years across BMI subgroups
- No significant difference in effect of ertugliflozin on HHF across BMI subgroups
- No significant difference in effect of ertugliflozin on kidney composite across BMI subgroups
- Results similar for other CV outcomes
- Ertugliflozin vs Placebo: P for interaction = 0.61
- Ertugliflozin vs Placebo: P for interaction = 0.39
Further findings
| Outcome | Ertugliflozin | Placebo | OR (95% CI) | |
|---|---|---|---|---|
| ≥5% body weight reduction · 5 years | 34.9% | 19.4% | 2.21 (1.76–2.77) | |
| ≥10% body weight reduction · 5 years | 13.6% | 4.1% | 3.65 (2.39–5.57) | |
| 0.20.5125Odds ratio (log scale) |
- Absolute body weight reduction, overall population · 3 and 5 years · greater reduction with ertugliflozin
- P < 0.001
Safety
- Safety consistent with the known ertugliflozin profile
Original publication
Long‐term weight loss and cardiorenal outcomes by baseline BMI in the VERTIS CV trial. Diabetes Obes Metab. Published 18 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →