Real-world sex differences in type 2 diabetes patients treated with GLP-1 receptor agonists
Authors' conclusion
Although MACE rates were similar, the factors contributing to MACE differed by sex.
Study context
- Population
- T2D patients with and without established CVD, followed at a single center after first GLP-1 RA prescription; 43% women43% women
- Participants
- 550 patients
- Exposure
- Men vs women treated with GLP-1 RA
- Outcome
- Determinants of MACE in men and women
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Predictors of MACE by sex
| Group | Primary prevention: older age, HR (95% CI 1.05-1.22; P = 0.001) | Primary prevention: GLP-1 RA withdrawal by time, HR (95% CI 1.15-6.68; P = 0.023) | Prior CVD: GLP-1 withdrawal over time, HR (95% CI 1.10-4.30; P = 0.025) | Primary prevention: diabetes duration, HR (CI 1.01-1.10; P = 0.020) | Primary prevention: GLP-1 withdrawal by time, HR (95% CI 1.13-7.10; P = 0.026) | Primary prevention: BMI at GLP-1 RA withdrawal, HR (95% CI 1.01-1.15; P = 0.026) | Prior CVD: older age at GLP-1 RA initiation, HR (95% CI 1.03-1.33; P = 0.015) |
|---|---|---|---|---|---|---|---|
| Men | 1.13 | 2.77 | 2.18 | ||||
| Women | 1.05 | 2.84 | 1.08 | 1.17 |
Primary prevention: older age, HR (95% CI 1.05-1.22; P = 0.001)
Men1.13
Women— not stated in the abstract
Primary prevention: GLP-1 RA withdrawal by time, HR (95% CI 1.15-6.68; P = 0.023)
Men2.77
Women— not stated in the abstract
Prior CVD: GLP-1 withdrawal over time, HR (95% CI 1.10-4.30; P = 0.025)
Men2.18
Women— not stated in the abstract
Primary prevention: diabetes duration, HR (CI 1.01-1.10; P = 0.020)
Men— not stated in the abstract
Women1.05
Primary prevention: GLP-1 withdrawal by time, HR (95% CI 1.13-7.10; P = 0.026)
Men— not stated in the abstract
Women2.84
Primary prevention: BMI at GLP-1 RA withdrawal, HR (95% CI 1.01-1.15; P = 0.026)
Men— not stated in the abstract
Women1.08
Prior CVD: older age at GLP-1 RA initiation, HR (95% CI 1.03-1.33; P = 0.015)
Men— not stated in the abstract
Women1.17
Observational data: associations, not effects.
Original publication
Real-world sex differences in type 2 diabetes patients treated with GLP-1 receptor agonists. Diabetes Res Clin Pract. Published 1 May 2024. doi:10.
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