The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An Innovative Medicines Initiative (IMI) DIRECT Study
An erratum to this article was published (J Clin Endocrinol Metab, 13 Aug 2024 ↗)
Authors' conclusion
These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.
Study context
- Population
- People at risk of, or living with, T2D; two IMI DIRECT cohorts
- Participants
- 2,127 vs 789
- Exposure
- Cohort 1 vs Cohort 2
- Cohort 1n = 2,127
- Cohort 2n = 789
- Outcome
- Fasting and postprandial (incremental) GLP-1
Methodological detailsmultiple regression analysis
- Multiple regression analysis
Main finding
As reported in the abstract
- Fasting total GLP-1 associated with an insulin-resistant phenotype; strong independent relationship with male sex, increased adiposity and liver fat, particularly in the prediabetes population
- Incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex and reduced insulin sensitivity in the prediabetes cohort
- Higher fasting total GLP-1 associated with low intake of wholegrain, fruit and vegetables in prediabetes, and with high intake of red meat and alcohol in diabetes
Observational data: associations, not effects.
Original publication
The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study. J Clin Endocrinol Metab. Published 30 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →