Treatment trajectories for Danish individuals with type 2 diabetes in the era of emerging glucose‐lowering therapies
Authors' conclusion
Our study documents a trend towards earlier T2D treatment intensification and an increase in the use of GLP-1RAs and SGLT-2is in Denmark. However, optimal T2D treatment is still not received by most individuals with early T2D and established cardiorenal disease.
Study context
- Population
- People with HbA1c-confirmed T2D in Denmark filling a first-ever prescription for metformin, DPP-4i, GLP-1 RA, SGLT2i or insulin, 2016–2023; probable T1D excluded
- Participants
- 260,393 people
- Exposure
- Cardiorenal disease vs No cardiorenal disease
- Outcome
- Trends in initiators of glucose-lowering therapy classes, 2016–2023
Methodological detailsDanish health registries
- Danish health registries
Main finding
As reported in the abstract
- Increase in GLP-1 RA initiators
- 6-fold
- Increase in SGLT2i initiators
- 3-fold
- Median HbA1c at GLP-1 RA or SGLT2i initiation, 2016-2017
- 67-68 mmol/mol
- Median HbA1c at GLP-1 RA or SGLT2i initiation, 2022-2023
- 57-58 mmol/mol
- Metformin first-line initiators starting additional therapy within 2 years, 2016
- 25%
- Metformin first-line initiators starting additional therapy within 2 years, 2021
- 40%
Observational data: associations, not effects.
Further findings
SGLT2i and GLP-1 RA use after first-ever therapy initiated in 2020, by cardiorenal disease · 2.5 years
SGLT2i use
GLP-1 RA use
- SGLT2i and GLP-1 RA use after first-ever therapy initiated in 2020, by cardiorenal disease — Share with established cardiorenal disease at first-ever therapy in 2020
- 38%
- SGLT2i and GLP-1 RA use after first-ever therapy initiated in 2020, by cardiorenal disease: per_group value = SGLT2i use
Original publication
Treatment trajectories for Danish individuals with type 2 diabetes in the era of emerging glucose‐lowering therapies. Diabetes Obes Metab. Published 16 September 2024. doi:10.
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