Four-year trajectories of depressive symptoms and subsequent risk of hip fracture: evidence from China Health and Retirement Longitudinal Study
Authors' conclusion
A high-increasing depressive symptom trajectory was significantly associated with an increased risk of hip fracture, particularly among females.
Study context
- Population
- Individuals aged 45 and older from China Health and Retirement Longitudinal Study (CHARLS)CHARLS
- Participants
- 8,942 individuals
- Exposure
- Depressive symptom trajectories (2011-2015): moderate-stable and high-increasing vs low-stable
- Outcome
- Hip fracture risk over the subsequent 5 years, and whether the association differs by gender
- Follow-up
- 5 years
Methodological detailslongitudinal, nationally representative, group-based trajectory modeling, Cox proportional hazards models
- Longitudinal
- Nationally representative
- Group-based trajectory modeling
- Cox proportional hazards models
Main finding
As reported in the abstract
Hip fracture in females
Each group vs low-stableHazard ratio (95% CI)P value
High-increasing
2.37(1.29–4.35)
P < 0.01Moderate-stable
1.05(0.63–1.73)
P > 0.05Observational data: associations, not effects.
Further findings
- Sensitivity analyses supported these findings
Original publication
Four-year trajectories of depressive symptoms and subsequent risk of hip fracture: evidence from China Health and Retirement Longitudinal Study. Osteoporos Int. Published 23 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →