Association of frailty trajectories with osteoporosis and hip fracture in an older female population
An erratum to this article was published (Osteoporos Int, May 2026 ↗)
Authors' conclusion
These results suggest that frailty status is closely associated with the risk of osteoporosis and hip fracture, with poorer frailty status correlating with a higher risk of osteoporosis and hip fracture.
Study context
- Population
- Older female population, Health and Retirement Study (HRS) and English Longitudinal Study of Ageing (ELSA)
- Participants
- 4,949 / 2,717 / 1,937 / 624
- Exposure
- Pre-frailty, moderate frailty and severe frailty trajectories vs stable robust trajectory
- Stable robust trajectoryn = 4,949reference
- Pre-frailty trajectoryn = 2,717
- Moderate frailty trajectoryn = 1,937
- Severe frailty trajectoryn = 624
- Outcome
- Osteoporosis and hip fracture (self-reported physician diagnosis)
Methodological detailstwo prospective longitudinal cohorts (HRS and ELSA), biennial follow-up 2014–2018, group-based trajectory modeling, multivariate-adjusted logistic regression
- Two prospective longitudinal cohorts (HRS and ELSA)
- Biennial follow-up 2014–2018
- Group-based trajectory modeling
- Multivariate-adjusted logistic regression
Main finding
As reported in the abstract
Osteoporosis
Each group vs stable robust trajectoryOdds ratio (95% CI)
Pre-frailty trajectory
1.91(1.69–2.15)
Moderate frailty trajectory
3.02(2.6–3.52)
Severe frailty trajectory
5.39(4.1–7.07)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Hip fractureModerate frailty trajectoryvs Stable robust trajectoryCo-primary outcome (aim names both outcomes) | 2.55 (1.68–3.87) | |
| Hip fractureSevere frailty trajectoryvs Stable robust trajectoryCo-primary outcome (aim names both outcomes) | 6.03 (3.2–11.36) | |
| 0.050.21520Odds ratio (log scale) |
- Hip fracture: abstract wording does not name the outcome explicitly; read as hip fracture
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of frailty trajectories with osteoporosis and hip fracture in an older female population. Osteoporos Int. Published 9 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →