Association between cognitive trajectories and subsequent hip fracture risk: a multinational prospective cohort study
Authors' conclusion
Cognitive trajectories were related to subsequent hip fracture risk, particularly among individuals in the rapid-decline group. Early identification and targeted management of unfavorable cognitive trajectories may contribute to hip fracture prevention among middle-aged and older adults.
Study context
- Population
- Participants aged ≥ 45 years from three prospective cohorts in China, the United States, and the United Kingdomparticipants included
- Participants
- 14,282 participants
- Exposure
- Moderate-decline and rapid-decline cognitive trajectories relative to the high-stable trajectory
- High-stablen = 8,317reference
- Moderate-declinen = 4,725
- Rapid-declinen = 1,240
- Outcome
- Hip fracture risk
Methodological detailsthree nationally representative prospective cohorts
- Three nationally representative prospective cohorts
Main finding
As reported in the abstract
Each group vs high-stableHazard ratio (95% CI)
Moderate-decline
1.39(1.05–1.84)
Rapid-decline
1.86(1.27–2.74)
Observational data: associations, not effects.
Further findings
Distribution of cognitive trajectories
Original publication
Association between cognitive trajectories and subsequent hip fracture risk: a multinational prospective cohort study. Osteoporos Int. Published 13 November 2026. doi:10.
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