First year national Swedish paediatric Hba1c data are at the level of several intervention studies: Results from a Swedish nationwide diabetes register study
Authors' conclusion
There was a continuous decrease in HbA1c over the study period 2010-2019, which coincides in time with an increased use of diabetes technology and lowering the HbA1c target to 48 mmol/mol (6.5 %). The decrease in 2-year HbA1c was preceded by a lower HbA1c nadir, which may set the trajectories for coming HbA1c and be a modifiable factor for a long-term improvement in metabolic control.
Study context
- Population
- Children and adolescents (up to 18 years) with T1D diagnosed 2010–2019, Swedish paediatric diabetes quality register SWEDIABKIDS48,292 HbA1c values
- Participants
- 6,891 children
- Exposure
- Onset year periods 2010/11 vs 2018/19
- Outcome
- Progression of HbA1c after T1D diagnosis, with emphasis on HbA1c nadir 3-6 months after onset
- Follow-up
- Two years from onset
Methodological detailsSWEDIABKIDS register (>95 % coverage), mixed model for repeated measurements
- SWEDIABKIDS register (>95 % coverage)
- Mixed model for repeated measurements
Main finding
As reported in the abstract
2010/11
56.0
mean · mmol/mol (7.28 %)
2018/19
50.5
mean · mmol/mol (6.77 %)
Observational data: associations, not effects.
Further findings
Correlation of HbA1c at 3 and 6 months with 12, 18 and 24 months
- Significant positive correlation
Safety
Severe hypoglycaemic coma · higher in 2010/2011
P = 0.023
Ketoacidosis (absolute risk) · essentially unchanged
P = 0.110
Original publication
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