Partial Clinical Remission of Type 1 Diabetes in Swedish Children: A Longitudinal Study from the Swedish National Quality Register (SWEDIABKIDS) and the Better Diabetes Diagnosis (BDD) Study
Authors' conclusion
Insulin through MDI, longer duration of diabetes, and female sex were associated with lower frequency of partial remission. Use of CSII seems to contribute to longer partial remission among Swedish children with type 1 diabetes.
Study context
- Population
- Newly diagnosed Swedish children with T1D, SWEDIABKIDS 2007–2020; 56% boys
- Participants
- 3,887 participants
- Exposure
- Continuous subcutaneous insulin infusion (CSII) vs MDI
- Outcome
- Partial remission (insulin dose-adjusted HbA1c: HbA1c (%) + [4 × total daily insulin dose (U/kg/day)] ≤9)
Methodological detailsnational quality register (SWEDIABKIDS), C-peptide data from BDD study
- National quality register (SWEDIABKIDS)
- C-peptide data from BDD study
Main finding
As reported in the abstract
Remained in partial remission · 12 months
P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | OR for partial remission (CI) | |
|---|---|---|
| Factors associated with partial remission at 12 months · 12 months after onsetCSIIvs MDI | 1.39 (1.13–1.71) | |
| Factors associated with partial remission at 12 months · 12 months after onsetMale sexvs Female sex | 1.23 (1.04–1.46) | |
| 0.512OR for partial remission (log scale) |
- Factors associated with partial remission at 12 months — Shorter diabetes duration associated with partial remission
- 0.80 (OR for partial remission, CI: 0.76, 0.84)
Partial remission by sex and age · up to 24 months after onset
- More boys than girls were in partial remission throughout follow-up until 24 months after onset
- Fewer children 0-6 years old had partial remission at 3 and 12 months, but not at 24 months, vs older age-groups
C-peptide and HbA1c by partial remission status
- C-peptide higher and mean HbA1c lower with partial remission (both P < 0.001)
Original publication
Partial Clinical Remission of Type 1 Diabetes in Swedish Children: A Longitudinal Study from the Swedish National Quality Register (SWEDIABKIDS) and the Better Diabetes Diagnosis (BDD) Study. Diabetes Technol Ther. Published 26 June 2024. doi:10.
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