Human leukocyte antigen (HLA) investigation in ICI-induced T1D and isolated ACTH deficiency including meta-analysis
Authors' conclusion
This study revealed specific HLA signatures associated with ICI-T1D and ICI-IAD. Moreover, HLA-DRB1*15:02-DRB1*06:01, an ICI-IAD-susceptible HLA haplotype, coincides with the ICI-T1D-protective HLA haplotype, suggesting that the presence of DRB1*15:02-DRB1*06:01 may protect against the co-occurrence of T1D in patients with ICI-IAD.
Study context
- Population
- Patients with ICI-induced T1D and/or isolated ACTH deficiency
- Participants
- 22 / 14 / 11
- Comparison
- HLA signatures in ICI-T1D vs ICI-IAD vs ICI-T1D/IAD
- ICI-T1Dn = 22
- ICI-IADn = 14
- ICI-T1D/IADn = 11
- Outcome
- Frequencies of HLA signatures
Methodological detailsincludes cases from nationwide reports
- Includes cases from nationwide reports
Pooled result
As reported in the abstract
HLA associations
- ICI-T1D: HLA-DRB1*09:01-DQB1*03:03 and DQA1*03:02 (in linkage disequilibrium with DRB1*09:01-DQB1*03:03 and DRB1*13:02-DQB1*06:04) susceptible
- ICI-T1D: DRB1*15:02-DQB1*06:01 protective
- ICI-IAD: DPB1*09:01, C*12:02-B*52:01 and DRB1*15:02-DRB1*06:01 (strong linkage disequilibrium) associated with susceptibility
- ICI-T1D/IAD: DRB1*15:02-DRB1*06:01 not detected
Original publication
HLA investigation in ICI-induced T1D and isolated ACTH deficiency including meta-analysis. Eur J Endocrinol. Published 25 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →