Metabolic dysfunction‐associated steatotic liver disease is associated with worse time in ranges in type 1 diabetes
Authors' conclusion
TIR, TAR, TBR, waist circumference and systolic blood pressure were independently associated with MASLD.
Study context
- Population
- Adults with T1D using a continuous glucose monitoring (CGM) device; median age 49 [34–61] years, male sex 58%, median diabetes duration 29 [17–38] yearsconsecutive
- Participants
- 302 adults
- Exposure
- MASLD vs no MASLD
- Outcome
- Relationship between CGM-derived glucometrics and MASLD
Methodological detailsconsecutive participants, backward multivariable logistic regression
- Consecutive participants
- Backward multivariable logistic regression
Main finding
As reported in the abstract
- TIR independently associated with MASLD
- P = .028
- Time above range (TAR) independently associated with MASLD
- P = .007
- Time below range (TBR) independently associated with MASLD
- P = .036
- Waist circumference independently associated with MASLD
- P < .001
- Systolic blood pressure independently associated with MASLD
- P = .029
Observational data: associations, not effects.
Further findings
MetS prevalence
P < 0.0001
- Glucometrics, univariable comparison · TIR lower with MASLD
- P = 0.038
- Glucometrics, univariable comparison · TBR lower with MASLD
- P = 0.032
- Glucometrics, univariable comparison · TAR higher with MASLD
- P = 0.006
- Glucometrics, univariable comparison · HbA1c did not reach significance
- P = 0.068
- Glucometrics, univariable comparison — Mean TIR, whole cohort
- 55% ± 16%
MASLD prevalence
- MASLD present
- 17%
- Metabolic syndrome (MetS)
- 32%
Glucometrics, univariable comparison
- No differences for the glycaemia risk index
Original publication
Metabolic dysfunction‐associated steatotic liver disease is associated with worse time in ranges in type 1 diabetes. Diabetes Obes Metab. Published 25 June 2024. doi:10.
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