Family history of diabetes mellitus and risk of colorectal cancer: A nationwide cohort study
Authors' conclusion
Leveraging one of the world's largest family-disease datasets, our cohort study confirmed that personal history of diabetes is associated with an increased risk of colorectal cancer, but we did not find an association between a family history of diabetes and risk of colorectal cancer.
Study context
- Population
- Individuals in Swedish nationwide registers, follow-up 1964–2018; followed up to 54 years (median = 28 years)668,348 with DM
- Participants
- 11,784,567 individuals
- Exposure
- Family history of DM vs none; personal history of DM vs none
- Personal history of DMn = 668,348
- Outcome
- Risk of CRC by family history of DM
Methodological detailsSwedish nationwide registers, standardized incidence ratio (SIR)
- Swedish nationwide registers
- Standardized incidence ratio (SIR)
Main finding
As reported in the abstract
CRC risk with family history of DM
- Addition of a family history of DM in 1 FDR or ≥ 2 FDRs did not significantly alter the increased risk of early-onset or late-onset colorectal cancer (CRC)
Observational data: associations, not effects.
Further findings
| Outcome | SIR (95 % CI) | |
|---|---|---|
| CRC risk with personal history of DM1.4-fold increased risk | 1.4 (1.39–1.45) | |
| 0.512Standardized incidence ratio (log scale) |
Original publication
Family history of diabetes mellitus and risk of colorectal cancer: A nationwide cohort study. Diabetes Res Clin Pract. Published 17 April 2025. doi:10.
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