Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities
Authors' conclusion
Several factors in acromegaly may affect brain structure, promoting WMH development, such as aging, disease duration, and hypertension. Therefore, in patients with acromegaly, we suggested the early management of cardiovascular comorbidities and regular radiological follow-up, not limited to the study of the pituitary gland. Future prospective studies are necessary to confirm our preliminary observations and to clarify the potential role of disease activity and treatment in WMH development.
Study context
- Population
- Patients with acromegaly who underwent gadolinium-enhanced brain MRI
- Participants
- 37 patients
- Exposure
- Acromegaly patients with white matter hyperintensities (WMHs) vs without WMHs
- WMHsn = 24
- Outcome
- Presence of WMHs in patients with acromegaly
Main finding
As reported in the abstract
WMHs found
24 patients
64.9%
Higher lesion burden
9 patients
Observational data: associations, not effects.
Further findings
Age · older with WMHs
P = 0.023
Disease duration · longer with WMHs
P = 0.028
Comorbidities
- Hypertension
- 22/37
- Migraine
- 18/37
Association of WMHs with hypertension and migraine
- Higher WMH burden significantly associated with hypertension
- P = 0.05
- No significant link between WMHs and migraine
- P > 0.05
Original publication
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