Temporal and masseter muscle evaluation by MRI provides information on muscle mass and quality in acromegaly patients
Authors' conclusion
Male patients with higher IGF-1 values have thicker temporal and masseter muscles, suggesting that sex and IGF-1 have a significant impact on muscle mass in acromegaly.
Study context
- Population
- Patients with acromegaly with at least one available brain/sella turcica MRI and matched clinical data182 MRIs analysed
- Participants
- 69 patients
- Outcome
- Relationship between temporal (TMT) and masseter muscle thickness (MMT) and clinical/biochemical characteristics
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Baseline: TMT and MMT higher in males than females
- p = 0.001 and p = 0.016, respectively
- Baseline: TMT and MMT positively associated
- β 0.508, p < 0.001
- Baseline: TMT and MMT positively correlated with IGF-1 xULN
- TMT, p = 0.047; MMT, p = 0.001
- Baseline: MMT positively correlated with weight and height
- p = 0.015; p = 0.006
- All MRIs, multivariable: female sex (TMT/MMT)
- β −0.345/−0.426, p < 0.001
- All MRIs, multivariable: IGF-1 xULN (TMT/MMT)
- β 0.257/0.328, p < 0.001
Observational data: associations, not effects.
Further findings
MMT change over time in patients uncontrolled at baseline · longitudinal
- Significant reduction of MMT over time
- P = 0.044
Remarkable muscle fatty infiltration (modified Goutallier score)
- Proportion of MRIs with remarkable fatty infiltration
- 34-37%
- Age as determinant, temporal muscle
- OR 1.665; p = 0.013
- Age as determinant, masseter muscle
- OR 1.793; p = 0.009
- Age was the main determinant
Original publication
Temporal and masseter muscle evaluation by MRI provides information on muscle mass and quality in acromegaly patients. Pituitary. Published 5 July 2024. doi:10.
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