Muscle dysfunction is associated with poor quality of life in long-term controlled patients with acromegaly
Authors' conclusion
Muscle dysfunction in long-term controlled ACRO patients negatively affects QoL, underscoring the need for routine functional assessments and targeted rehabilitation strategies.
Study context
- Population
- Long-term controlled acromegaly patients (normalized IGF-I levels and suppressed GH concentrations after an OGTT); 14 males, 22 females; mean age 54 ± 8 years; mean (± SD) control duration 8 (4) years
- Participants
- 36 participants
- Outcome
- Association between muscle function (GS, TUG, handgrip strength (HGS), 30-second chair-to-stand test) and QoL (AcroQoL, SF-36)
Main finding
As reported in the abstract
Muscle function and QoL
- Poor muscle performance, particularly on gait speed (GS) and timed up and go (TUG), significantly associated with reduced quality of life (QoL) scores on physical, psychological and social domains of AcroQoL and SF-36
- Women: mobility limitations linked to impaired self-image and physical functioning
- Men: reduced muscle strength and mobility associated with broad QoL alterations on physical and emotional dimensions
Observational data: associations, not effects.
Original publication
Muscle dysfunction is associated with poor quality of life in long-term controlled patients with acromegaly. Pituitary. Published 29 May 2025. doi:10.
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