The USP8 Mutational Status in Combination With Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease
Authors' conclusion
Our study corroborates USP8 mutational status in combination with postsurgical MSC or 1-mg DST as independent predictors of long-term remission, highlighting their potential role in stratifying patients at risk for suboptimal outcomes.
Study context
- Population
- Patients with pathologically confirmed corticotroph adenomas (Cushing disease (CD)) after surgery
- Participants
- 107 patients
- Exposure
- USP8-mutated vs USP8 wildtype corticotroph adenomas
- Outcome
- Recurrence of CD; predictors of recurrence
Main finding
As reported in the abstract
Recurrence · mean follow-up 65 months after surgery
P = 0.009
- Overall recurrence
- 13 (12.6%)
Observational data: associations, not effects.
Further findings
Recurrence with USP8 mutation combined with high postsurgical morning serum cortisol (MSC) (>2.5 μg/dL) or high 1-mg dexamethasone suppression test (DST) (>0.78 μg/dL)
- More prone to recurrence (Kaplan-Meier, log-rank)
- log-rank P < .001
- NPV (MSC; DST combinations)
- 98% and 100%
- PPV improved, MSC combination
- from 33% to 55%
- PPV improved, DST combination
- from 47% to 86%
Original publication
The USP8 Mutational Status in Combination With Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease. J Clin Endocrinol Metab. Published 27 May 2025. doi:10.
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