Evaluation of a mass spectrometry-based method for estradiol determination in girls with benign premature thelarche – a method comparison with extraction radioimmunoassay (RIA)
Main finding · Agreement of estradiol concentrations between MS-based method and extraction RIAResult — go to the resultMean difference 5.3 (±2.7) pmol/LAuthors' conclusion
The estradiol upper limit level for what is considered benign in premature thelarche, obtained with extraction RIA, needs to be lowered when analyzed with high sensitivity MS-based methods.
Study context
- Population
- Girls aged 6–48 months with premature thelarche, Sweden
- Participants
- 43 serum samples
- Exposure
- High-sensitivity mass spectrometry (MS)-based estradiol assay vs extraction RIA
- Outcome
- Performance of the MS-based estradiol method in comparison with extraction RIA
Methodological detailsprospective, observational
- Prospective
- Observational
Main finding
As reported in the abstract
Agreement of estradiol concentrations between MS-based method and extraction RIA
Mean difference
5.3 (±2.7) pmol/L
- Significant correlation between the two methods, r
- 0.67, p=0.000
Observational data: associations, not effects.
Original publication
Evaluation of a mass spectrometry-based method for estradiol determination in girls with benign premature thelarche – a method comparison with extraction RIA. Horm Res Paediatr. Published 27 August 2026. doi:10.
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