Circulating miR-1-3p precedes adrenarche and modulates adrenocortical steroidogenesis via protein kinase C signaling
Main finding · Serum miR-1-3p levelsResult — go to the resultFold change 2Authors' conclusion
Elevated circulating miR-1-3p precedes clinical adrenarche and enhances steroidogenesis in vitro.
Study context
- Population
- Children in the population-based PANIC study, followed at ages 7, 9 and 15 years; cases 20 girls, controls 11 girls
- Participants
- 34 vs 24
- Exposure
- Children with signs of adrenarche at age 9 vs age-matched controls
- Casesn = 34
- Controlsn = 24reference
- Outcome
- Longitudinal serum miRNA expression and in vitro effects of candidate microRNAs (miRNAs) on adrenal steroidogenesis and gene expression
- Follow-up
- Ages 7, 9, and 15 years
Methodological detailsnested within the population-based PANIC study, longitudinal follow-up, age-matched controls, combined with in vitro experimental analyses (NCI-H295R cells)
- Nested within the population-based PANIC study
- Longitudinal follow-up
- Age-matched controls
- Combined with in vitro experimental analyses (NCI-H295R cells)
Main finding
Serum miR-1-3p levels · age 7 years
Fold change
2
P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Serum miR-1-3p over time
- In both groups, miR-1-3p levels declined during adrenarchal and pubertal development
In vitro miR-1-3p overexpression (NCI-H295R)
- Increased steroidogenic activity (approximately, on average)
- 1.5-fold
- Upregulated genes
- 208
- Downregulated genes
- 140
- No change in expression of canonical steroidogenic enzyme genes
- Genes identified include PRKCA (encoding protein kinase C (PKC)), enriched in the zona reticularis (ZR) and involved in steroidogenic signaling
Original publication
Circulating miR-1-3p precedes adrenarche and modulates adrenocortical steroidogenesis via protein kinase C signaling. J Clin Endocrinol Metab. Published 19 August 2026. doi:10.
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