Differentiation of Idiopathic Central Precocious Puberty From Premature Thelarche Using Principal Component Analysis
Authors' conclusion
Differentiation of girls with ICPP and PT can be supported by individual clinical and biochemical parameters. However, dimension reduction of clinical and hormonal profiles by PCA improved the diagnostic value, which in the future may support the diagnostic process as a supplement to the GnRH test in evaluation of pubertal disorders.
Study context
- Population
- Girls referred with signs of early puberty to a single tertiary centre, 2009–2019girls referred
- Participants
- 1,361 girls
- Exposure
- Idiopathic central precocious puberty (ICPP) vs premature thelarche (PT): single clinical and biochemical markers vs principal component analysis (PCA)-derived clinical and hormone profiles
- ICPPn = 143
- PTn = 91reference
- Outcome
- Prediction of ICPP vs PT by PCA-derived clinical and hormone profiles
Methodological detailssingle-centre, tertiary centre, diagnostic accuracy
- Single-centre
- Tertiary centre
- Diagnostic accuracy
Main finding
As reported in the abstract
PCA-derived profiles: specificity
90%
PCA-derived profiles: sensitivity
84%
Observational data: associations, not effects.
Further findings
Diagnoses among referred girls
- Central precocious puberty
- 11%
- ICPP
- 143
- Organic CPP
- 11
- PT
- 8% (n = 91)
Single markers (ROC analysis)
- Several biochemical and anthropometric markers were potential parameters to differentiate ICPP from PT; none was individually adequate
Original publication
Differentiation of Idiopathic Central Precocious Puberty From Premature Thelarche Using Principal Component Analysis. J Clin Endocrinol Metab. Published 12 September 2023. doi:10.
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