Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls
Authors' conclusion
Circulating miR-30b-5p levels and its bioactivity followed the activity of the HPG axis during minipuberty and puberty, and miR-155-5p levels showed a similar pattern during puberty, suggesting regulatory roles on the HPG axis in girls.
Study context
- Population
- Healthy girls: 18 female infants (COPENHAGEN Minipuberty Study) sampled during and after minipuberty; 29 girls (Copenhagen Puberty Study) sampled at pre-, peri- and late puberty
- Outcome
- Circulating serum miR-30b-5p and miR-155-5p levels (RT-qPCR, 2 methods)
- Follow-up
- Minipuberty and puberty
Main finding
As reported in the abstract
- miR-30b-5p decreased significantly after cessation of minipuberty, with lower phosphorylation (suggesting decreased bioactivity)
- P < .05
- miR-30b-5p increased significantly at late puberty vs pre- and peri-puberty
- P < .01
- miR-155-5p increased significantly in late puberty vs pre- and peri-puberty
- P < .01
Observational data: associations, not effects.
Original publication
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls. J Clin Endocrinol Metab. Published 3 September 2025. doi:10.
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