Premature adrenarche and metabolic risk: a systematic review and meta-analysis
Pooled result · Body composition and metabolic markersResult — go to the resultMD 15.04 pmol/L 95% CI 5.27–24.81Authors' conclusion
Children with PA are taller, heavier, and have higher FI levels than their healthy peers at presentation. We observed significant heterogeneity of reported outcomes with generally small participant numbers in the included studies. Large-scale studies with comprehensive, unified assessment and long-term follow-up are needed to explore the extent of metabolic dysfunction that may develop over time.
Study context
- Population
- Children (boys and girls) with premature adrenarche (PA); studies 1990–March 202525 case-control studies
- Participants
- 694 vs 567
- Comparison
- Children with premature adrenarche vs healthy controls
- PAn = 694
- Controlsn = 567reference
- Outcome
- Surrogate parameters of metabolic risk: body composition and markers of glucose and lipid metabolism
Methodological detailstwo independent reviewers, study quality appraisal
- Two independent reviewers
- Study quality appraisal
Pooled result
Body composition and metabolic markers
MD
15.04 pmol/L
95% CI 5.27–24.81
PAvs Controls
MD 15.04 pmol/L (95% CI 5.27–24.81)
As reported in the abstract
Original publication
Premature adrenarche and metabolic risk: a systematic review and meta-analysis. Eur J Endocrinol. Published 30 August 2025. doi:10.
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