Adrenal androgens as predictors of growth characteristics in premature pubarche
Authors' conclusion
Isolated idiopathic PP appears to be a benign variant of normal development. In this setting, adrenal androgen concentrations are not associated with adverse linear growth outcomes and are unlikely to influence clinical management, supporting a conservative approach after exclusion of pathological causes.
Study context
- Population
- Girls with isolated premature pubarche, assessed at presentation and during follow-up
- Participants
- 53 vs 36
- Exposure
- Girls with isolated premature pubarche (PP) vs age-matched girls without PP
- PPn = 53
- Controlsn = 36reference
- Outcome
- Predictive value of adrenal androgens (DHEA, dehydroepiandrosterone-sulfate (DHEA-S), A4, androsterone, 11OHA4, 11OHT) for growth characteristics
Methodological detailsage-matched controls, liquid chromatography-mass spectrometry
- Age-matched controls
- Liquid chromatography-mass spectrometry
Main finding
As reported in the abstract
Corrected height SDS correlated with baseline corrected height SDS
r = .63
P < .0001
Corrected height SDS correlated with baseline bone age (BA)/chronological age ratio
r = .31
P = .02
Corrected height SDS correlated with baseline BA SDS
r = .32
P = .01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Height, BMI-SDS, DHEA, DHEA-S, A4, androsterone and 17OH-pregnenoloneHigher with PP | P < 0.0001 |
11OHA4 and 11OHT concentrations
- No difference in 11OHA4 and 11OHT between PP and controls
Original publication
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