Prevalence of Adrenal Pathology in Children Referred for Premature Pubarche: A 10-Year Retrospective Review in an Indiana Cohort
Authors' conclusion
Adrenal pathology among children referred for PP is exceedingly rare. Routine laboratory testing in the absence of additional signs of androgen exposure is not warranted.
Study context
- Population
- Children referred for premature pubarche to pediatric endocrine clinics, January 2015–December 2024, Indiana
- Participants
- 1,160 children
- Exposure
- Adrenal pathology vs premature adrenarche
- Outcome
- Prevalence of adrenal pathology
Methodological detailsretrospective chart review
- Retrospective chart review
Main finding
As reported in the abstract
Adrenal pathology, all diagnosed with CAH
6
0.52%
Observational data: associations, not effects.
Further findings
Male sex
Age at presentation
- Did not differ between premature adrenarche (PA) and pathology groups
Mean BMI z-score
- Trend toward lower mean BMI z-scores with pathology
Original publication
Prevalence of Adrenal Pathology in Children Referred for Premature Pubarche: A 10-Year Retrospective Review in an Indiana Cohort. Horm Res Paediatr. Published 31 December 2025. doi:10.
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