Epigenome‐wide association study of BMI in Black populations from InterGEN and GENOA
Authors' conclusion
This study suggests that BMI is associated with differences in DNAm among women that can be identified with DNA extracted from salivary (discovery) and peripheral blood (replication) samples among Black populations across two cohorts.
Study context
- Population
- Black populations from two cohorts (InterGEN and GENOA)
- Participants
- 239 vs 961
- Comparison
- InterGEN vs GENOA
- InterGENn = 239
- GENOAn = 961
- Outcome
- Association of BMI with epigenome-wide DNA methylation (850K Illumina EPIC BeadChip)
Methodological detailscross-sectional, discovery and replication cohorts, meta-analysis, Linear mixed-effects regression adjusted for batch effects, cell type heterogeneity, population stratification and confounding factors
- Cross-sectional
- Discovery and replication cohorts
- Meta-analysis
- Linear mixed-effects regression adjusted for batch effects, cell type heterogeneity, population stratification and confounding factors
Pooled result
As reported in the abstract
DNAm sites significantly associated with BMI
Sites associated with BMI in InterGEN discovery cohort
28
Previously unreported among these
24
Replicated in GENOA
17
Further pooled results
Meta-analysis (InterGEN + GENOA) DNA methylation (DNAm) sites associated with BMI
- Sites with false discovery rate < 0.05, combined sex
- 658
- Sites significantly associated, Black women
- 628
- Bonferroni-corrected p value 0.05, combined sex
- 65
- Bonferroni-corrected p value 0.05, female-only
- 61
Original publication
Epigenome‐wide association study of BMI in Black populations from InterGEN and GENOA. Obesity (Silver Spring). Published 7 December 2022. doi:10.
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