Association of Type 2 Diabetes Subgroups With Cognitive Status Without Modification From Lifestyle Intervention
Authors' conclusion
Among individuals with T2D and overweight or obesity, probability of MCI/PD differed by T2D subgroup. Probability of MCI/PD was highest for a subgroup characterized by severe obesity.
Study context
- Population
- Look AHEAD participants with T2D and overweight or obesity randomly assigned to 10 years of intensive lifestyle intervention (ILI) or diabetes support and education
- Participants
- 3,760 participants
- Comparison
- T2D subgroups; modification by ILI vs diabetes support and education
- Primary endpoint
- Prevalent MCI/PD, centrally adjudicated
- Follow-up
- 10 to 13 years after randomization
Methodological detailsk-means clustering, centrally adjudicated outcomes
- K-means clustering
- Centrally adjudicated outcomes
Primary result
As reported in the abstract
Unadjusted prevalence of MCI/PD
- Overall mild cognitive impairment (MCI)/probable dementia (PD) cases
- 314 cases, 8.4%
Further findings
| Outcome | P value |
|---|---|
| Modification of subgroup association by ILI armILI vs Diabetes support and education · did not differ by ILI arm | interaction P value = 0.84 |
Original publication
Association of Type 2 Diabetes Subgroups With Cognitive Status Without Modification From Lifestyle Intervention. J Clin Endocrinol Metab. Published 6 December 2022. doi:10.
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