Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents
Authors' conclusion
In this secondary analysis, in youth with obesity, adipose tissue insulin resistance is not protective from increases of the degree of obesity and skeletal muscle insulin resistance is not associated with increases of the degree of obesity.
Study context
- Population
- Youth with obesity at a pediatric weight management clinic
- Participants
- 213 participants
- Comparison
- Adipose tissue insulin sensitivity/resistance and whole-body insulin sensitivity (oral glucose tolerance test (OGTT)-derived surrogates) vs change in degree of obesity
- Primary endpoint
- Change in BMI z score
Methodological detailssingle-centre pediatric weight management clinic
- Single-centre pediatric weight management clinic
Primary result
As reported in the abstract
follow-up 1.88 ± 1.27 years
Mean body mass index (BMI) z change
0.05 ± 0.28
range, −1.15 to 1.19
Further findings
Postprandial free fatty acids
- Low postprandial free fatty acid concentrations or their suppression during the OGTT not associated with changes in degree of obesity in univariate or multivariate analyses
Whole-body insulin sensitivity
- Whole-body insulin sensitivity not associated with changes in degree of obesity in univariate or multivariate analyses
Original publication
Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents. J Clin Endocrinol Metab. Published 5 December 2022. doi:10.
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