Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study
Authors' conclusion
Participants with type 2 diabetes with evidence of remission had a substantially lower incidence of CKD and CVD, respectively, compared with participants who did not achieve remission. This association may be affected by post-baseline improvements in weight, fitness, HbA1c and LDL-cholesterol.
Study context
- Population
- Adults with T2D in the Look AHEAD RCT (12-year intensive lifestyle intervention vs diabetes support and education); 58% female, mean age 59 years, diabetes duration 6 years, BMI 35.8 kg/m²4,402 (CVD), 4132 (chronic kidney disease (CKD))
- Comparison
- Any diabetes remission vs no remission
- Primary endpoint
- Incidence of high-risk or very high-risk CKD (Kidney Disease Improving Global Outcomes (KDIGO)) and of CVD (non-fatal acute MI, stroke, admission for angina or CVD death)
Methodological detailsmulticentre, post hoc observational analysis, multivariate adjusted
- Multicentre
- Post hoc observational analysis
- Multivariate adjusted
Primary result
As reported in the abstract
Remission vs No remissionHazard ratio (95% CI)
CKD; 33% lower rate
0.67(0.52–0.87)
Composite CVD; 40% lower rate
0.60(0.47–0.79)
Further findings
Duration of remission
- Risk reduction greatest with longer-term remission
Original publication
Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study. Diabetologia. Published 18 January 2024. doi:10.
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