Medical and surgical treatment of postbariatric hypoglycaemia: Retrospective data from daily practice
Authors' conclusion
In daily practice, pharmacotherapy for PBH was successful in half to three quarters of patients. Combination therapy was often of value. One in five patients finally needed a surgical procedure, with overall good results.
Study context
- Population
- Patients with postbariatric hypoglycaemia (PBH) (neuroglycopenic symptoms with documented postprandial glucose <3.0 mmol/L after bariatric surgery); mean baseline age 41 years, total weight loss 33%, glucose nadir 2.3 mmol/Lmedian follow-up 27 months
- Participants
- 120 patients
- Exposure
- Medical and surgical treatment of PBH
- Surgical interventionn = 23
- Outcome
- Efficacy of treatment
Methodological detailsmulticentre, four hospitals, Data scored semiquantitatively on efficacy and side effects by two reviewers independently
- Multicentre
- Four hospitals
- Data scored semiquantitatively on efficacy and side effects by two reviewers independently
Main finding
As reported in the abstract
Overall efficacy of pharmacotherapy
45%-75% of patients
Efficacy of surgical procedures, pooled
79%
Median duration of initial effect of surgery
13 months
Observational data: associations, not effects.
Further findings
Combination therapy with two drugs
- Used combination therapy with two drugs
- 30 (25%) patients
- Addition of a second drug successful
- over half of the patients
Individual drugs
- Median duration of use of octreotide
- 35 months
- Long-acting octreotide and GLP-1 RA scored best on efficacy and side effects
Referral for surgical intervention
- Referred for surgical intervention
- 23 (19%) patients
Original publication
Medical and surgical treatment of postbariatric hypoglycaemia: Retrospective data from daily practice. Diabetes Obes Metab. Published 7 December 2022. doi:10.
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