Endocrine dysfunction in long-term survivors of pediatric head and neck rhabdomyosarcoma
Authors' conclusion
The prevalence of pituitary dysfunction in HNRMS survivors is high, emphasizing the importance of systematic endocrine assessment during follow-up, including pubertal development and growth. Efforts should be made to further reduce extraneous irradiation to endocrine organs to prevent dysfunction later in life.
Study context
- Population
- Long-term survivors of pediatric head and neck rhabdomyosarcoma treated 1993–2017, ≥2 years of follow-up, without recurrent disease or secondary malignancymedian follow-up 9 years
- Participants
- 96 survivors
- Exposure
- Local treatment strategies: photon, proton external beam radiation, microscopically radical surgery with external irradiation, macroscopic radical surgery with brachytherapy
- Outcome
- Prevalence of endocrine dysfunction
Methodological detailsretrospective chart review
- Retrospective chart review
Main finding
As reported in the abstract
Any endocrinopathy
- Any endocrinopathy
- 35%
- Pituitary insufficiency among those with endocrinopathy
- 88%
- Peripheral (thyroid) insufficiency among those with endocrinopathy
- 6%
- Combined insufficiencies among those with endocrinopathy
- 6%
- Gonadal insufficiency
- 0
Observational data: associations, not effects.
Further findings
GHD
- GHD
- 31 (32%)
- Additional pituitary insufficiencies among those with GHD
- 12 (39%)
Central precocious puberty preceding anterior pituitary insufficiency (API)
- Central precocious puberty preceded API
- 8%
API by local treatment
- API in survivors given brachytherapy
- 0
Original publication
Endocrine dysfunction in long-term survivors of pediatric head and neck rhabdomyosarcoma. Eur J Endocrinol. Published 8 January 2025. doi:10.
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