Osteocalcin in Infancy and Early Childhood and Its Correlation With Later Growth and Body Composition: A Longitudinal Birth Cohort Study
Authors' conclusion
Early levels of osteocalcin showed inverse correlations with later weight, height and body composition in infancy and positive correlations during childhood. The weak but consistent correlations suggest that osteocalcin carries information about future growth. Girls with high osteocalcin at 3 and 5 years had a larger fat mass at 8 years, while boys, in contrast, had a larger lean mass. These sex differences need to be further explored.
Study context
- Population
- Swedish children with blood samples from birth to 5 years; anthropometry up to 8 years and DXA at 8 years
- Participants
- 551 children
- Exposure
- Boys vs Girls
- Outcome
- Correlation of osteocalcin in infancy and early childhood with childhood growth and body composition (Spearman's rho)
Methodological detailsSwedish
- Swedish
Main finding
As reported in the abstract
- Girls: osteocalcin at 4 months correlated inversely only with weight at 4 months and waist circumference at 6 and 18 months
- ρ < 0.3, p = 0.001 to 0.048
- Boys: osteocalcin at 5 years correlated positively with height and weight at 5 and 6.5 years
- ρ < 0.3, p < 0.01
- Girls: osteocalcin at 3 years correlated positively with all weight and height measurements until 8 years
- ρ < 0.3, p = 0.003 to 0.023
- Boys: osteocalcin at 5 years correlated with fat-free mass index (FFMI) at 8 years (DXA), not with fat mass index (FMI)
- ρ 0.212, p = 0.026
- Girls: osteocalcin at 3 years correlated with FMI at 8 years (DXA), not with FFMI
- ρ 0.222, p = 0.020
Observational data: associations, not effects.
Original publication
Osteocalcin in Infancy and Early Childhood and Its Correlation With Later Growth and Body Composition: A Longitudinal Birth Cohort Study. Clin Endocrinol (Oxf). Published 27 December 2024. doi:10.
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