Endocrine Comorbidities in Survivors of Childhood Brain Tumors: Insights from the Slovenian National Cohort
Authors' conclusion
The findings highlight a high prevalence of endocrine disorders in childhood brain tumor survivors, particularly those with suprasellar or posterior fossa tumors, or those treated with radiotherapy. These results emphasize the need for regular and ongoing endocrine monitoring in this patient population following the completion of oncological treatment.
Study context
- Population
- Survivors of childhood primary brain tumors treated 2008–2018 at the University Children's Hospital, University Medical Center Ljubljana, evaluated by an endocrinologist in 2023/2024
- Participants
- 94 survivors
- Outcome
- Prevalence of endocrine disorders
- Follow-up
- Final
Methodological detailsnational cohort, single-centre
- National cohort
- Single-centre
Main finding
As reported in the abstract
Endocrine disorder prevalence
Diagnosed with an endocrine disorder
23%
Panhypopituitarism
10%
Observational data: associations, not effects.
Further findings
Factors associated with endocrine dysfunction
- More frequent with suprasellar tumors, radiotherapy and hydrocephalus
Height SDS vs baseline at treatment initiation
- Significant decrease in height SDS, p < 0.02
- More pronounced reduction after craniospinal radiotherapy
Original publication
Endocrine Comorbidities in Survivors of Childhood Brain Tumors: Insights from the Slovenian National Cohort. Horm Res Paediatr. Published 13 June 2025. doi:10.
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