Subtle Cognitive Impairments and Psychological Complaints in Patients With Prolactinoma Despite Biochemical Control
Authors' conclusion
Compared to matched controls, patients with biochemically controlled prolactinoma showed subtle cognitive impairments (ie, memory, attention, and processing speed) and reported more psychological complaints. Physicians should be aware of these impairments and address them adequately.
Study context
- Population
- Otherwise healthy patients with biochemically controlled prolactinoma; 41 (68.3%) females, aged 42.3 ± 11.7 yearsmatched controls
- Participants
- 60 vs 60
- Exposure
- Biochemically controlled prolactinoma vs matched controls
- Patientsn = 60
- Controlsn = 60reference
- Outcome
- Cognitive functioning (8 tests: memory, verbal fluency, processing speed, selective attention, executive functioning) and psychological complaints (7 validated questionnaires)
Methodological detailsage-, gender- and education level-matched controls
- Age-, gender- and education level-matched controls
Main finding
As reported in the abstract
Cognitive functioning
- Fewer words in patients
- β, verbal memory (words, Verbal Learning Test of Rey) −1.8 (95% CI −2.7 to −1.0)
- Fewer correct digits in patients
- β, selective attention (correct digits, Digit Deletion Test) −8.8 (95% CI −16.2 to −0.2)
- Longer time in patients
- β, selective attention (time, Trial Making Test A) 5.2 (95% CI 3.2–7.2)
- Fewer correct substitutions in patients
- β, processing speed (correct substitutions, Digit-Symbol Substitution Test) −4.2 (95% CI −8.2 to −0.2)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Psychological complaintsPatients vs Controls | β, apathy (Apathy Scale) 2.4 (95% CI 0.6–4.1) |
| Psychological complaintsPatients vs Controls | β, irritability (Irritability Scale) 2.2 (95% CI 0.3–4.1) |
| Psychological complaintsPatients vs Controls | β, fatigue (Fatigue Severity Scale) 6.7 (95% CI 2.7–10.8) |
| Psychological complaintsPatients vs Controls | β, anxiety (HADS) 1.1 (95% CI 0.1–2.1) |
| Psychological complaintsPatients vs Controls | β, depression (HADS) 1.7 (95% CI 0.8–2.7) |
Original publication
Subtle Cognitive Impairments and Psychological Complaints in Patients With Prolactinoma Despite Biochemical Control. J Clin Endocrinol Metab. Published 13 June 2025. doi:10.
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