Radiosurgery for PRL-secreting pituitary adenomas refractory to medical and surgical treatment
Authors' conclusion
Gamma Knife radiosurgery provides durable tumor control and hormonal improvement in patients with prolactinoma refractory to medical and surgical therapy. Side effects, including hypopituitarism, are uncommon.
Study context
- Population
- Patients with prolactinoma resistant to both dopamine agonists and surgery, tertiary reference centre
- Participants
- 44 consecutive patients
- Outcome
- Normalization of PRL on or off medical therapy, control of tumor growth, and toxicity
Methodological detailsconsecutive series, single tertiary reference centre
- Consecutive series
- Single tertiary reference centre
Main finding
As reported in the abstract
Probability of remission off drug therapy · median follow-up 92 months
- 5-year probability of remission off drug therapy
- 35.7% (95% CI 18.7%-52.7%)
- 10-year probability of remission off drug therapy
- 49.0% (95% CI 29.6%-68.4%)
- 5-year probability of remission on drug therapy, 20 patients
- 51.1% (95% CI 26.7%-75.5%)
- 10-year probability of remission on drug therapy, 20 patients
- 58.5% (95% CI 33.1%-83.9%)
- Tumor recurrence
- 3 patients (6.8%)
- 5-year recurrence-free survival
- 93.5% (95% CI 84.5%-100%)
- 10-year recurrence-free survival
- 88.6% (95% CI 75.8%-100%)
Observational data: associations, not effects.
Further findings
Spontaneous conception in women with infertility · during follow-up
- Spontaneously conceived, of 13 women with infertility
- 12 (92.3%)
Safety
Toxicity
- Severe trigeminal neuralgia lasting 6 months
- 1 patient
- New pituitary deficits
- 2 patients
Original publication
Radiosurgery for PRL-secreting pituitary adenomas refractory to medical and surgical treatment. Eur J Endocrinol. Published 17 June 2026. doi:10.
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