Endocrine disorders after treatment for pediatric brain tumors: long-Term outcomes and risk factors
Authors' conclusion
This study provides a comprehensive analysis of endocrine outcomes by tumor histotype, treatment modality, and onset timeline, underscoring the need for individualized and lifelong endocrine surveillance in survivors of childhood brain tumors.
Study context
- Population
- Patients diagnosed with primary brain tumors before 18 years of age, followed at a tertiary center 2000–2025
- Participants
- 388 patients
- Outcome
- Prevalence, risk factors and timing of onset of hypothalamic-pituitary disorders
Methodological detailssingle tertiary centre
- Single tertiary centre
Main finding
As reported in the abstract
Endocrine disorders
- Endocrine disorders (all patients)
- 75.8%
- Central hypothyroidism
- 27.8%
- Central precocious puberty
- 27.1%
- GHD
- 25.8%
- ACTH deficiency
- 22.7%
- Central diabetes insipidus
- 16.8%
Observational data: associations, not effects.
Further findings
Tumor histotype
- Glioma
- 66.2%
- Medulloblastoma
- 19.1%
- Ependymoma
- 6.2%
- Craniopharyngioma
- 5.2%
- Germ-cell tumors
- 3.3%
Timing of onset
- Early-onset deficiencies typically related to surgical hypothalamic-pituitary injury; late-onset disorders mainly associated with radiotherapy or chemotherapy
Risk factors
- Younger age at diagnosis and sellar/suprasellar localization independently predicted endocrine morbidity
Original publication
Endocrine disorders after treatment for pediatric brain tumors: long-Term outcomes and risk factors. J Clin Endocrinol Metab. Published 15 February 2026. doi:10.
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