Clinical, surgical, and endocrine outcome following treatment of posterior pituitary tumors: a retrospective cohort study
Authors' conclusion
PPTs are rare tumors with significant endocrine and metabolic consequences. While surgical management is associated with favorable tumor-specific survival, persistent endocrine dysfunction and postoperative progressive BMI underscore the need for long-term follow-up and targeted interventions. These findings contribute to the understanding of PPT biology and support the development of optimized management strategies.
Study context
- Population
- Patients with histologically confirmed posterior pituitary tumors (PPTs) treated at a single center, 2000–2023; 58% female, mean age 57.2 ± 13.2 years
- Participants
- 19 patients
- Exposure
- PC vs GCT vs SCO
- PCn = 3
- GCTn = 8
- SCOn = 8
- Outcome
- Surgical, survival and endocrine outcomes
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Gross total resection
58%
Tumor recurrence, all requiring adjuvant radiation therapy
16%
Tumor-specific survival at 5 years
100%
Overall survival
80%
Observational data: associations, not effects.
Further findings
| Outcome | PC | GCT | SCO | P value |
|---|---|---|---|---|
| Preoperative BMIGCT vs PC, SCO · higher with GCT | 22.12 ± 2.40 | 34.49 ± 5.72 | 24.74 ± 4.24 | P < 0.01 |
Postoperative BMI change
- Postoperative BMI increased across all groups, steepest rise with GCT (p < 0.01)
Presenting symptoms
- Headache
- 31.6%
- Visual impairment
- 21%
- Sexual dysfunction
- 10.5%
Surgical approach
- Transsphenoidal
- 48%
- Transcranial
- 52%
Original publication
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