The assessment of thiol-disulfide homeostasis and ıschemia-modified albumin levels in patients with acromegaly
Authors' conclusion
Our findings may indicate increased OS in the acromegalic process, which may contribute to the development of acromegaly and its related complications and comorbidities.
Study context
- Population
- Patients with acromegaly and healthy controls matched for age, gender and BMI
- Participants
- 81 vs 55
- Exposure
- Acromegaly patients vs healthy controls
- Patientsn = 81
- Controlsn = 55reference
- Outcome
- Serum TDH parameters (native thiol, total thiol, disulfide) and IMA levels
Methodological detailsconsecutive inclusion, matched for age, gender and BMI
- Consecutive inclusion
- Matched for age, gender and BMI
Main finding
As reported in the abstract
- Disulfide levels were similar
- Patients vs Controls: P = 0.005
- Patients vs Controls: P = 0.007
- Patients vs Controls: P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Active disease vs remission vs controls (post-hoc)Remission vs Controls · native thiol significantly lower in remission · post-hoc analyses | P = 0.01 |
| Active disease vs remission vs controls (post-hoc)Remission vs Controls · total thiol significantly lower in remission · post-hoc analyses | P = 0.04 |
| Active disease vs remission vs controls (post-hoc)Remission vs Controls · IMA significantly higher in remission · post-hoc analyses | P = 0.04 |
- Active disease vs remission vs controls (post-hoc): active disease N = 32, remission N = 49, controls N = 55
Active disease vs remission vs controls (post-hoc)
- Serum thiol-disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels similar in remission and active disease
Correlates of serum thiol levels
- Thiol positively correlated with IGF-1 and negatively with age and disease duration; age independently negatively affected thiol
Original publication
The assessment of thiol-disulfide homeostasis and ıschemia-modified albumin levels in patients with acromegaly. Pituitary. Published 5 April 2025. doi:10.
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