Elevated plasma hepcidin concentrations are associated with an increased risk of mortality and nonfatal cardiovascular events in patients with type 2 diabetes: a prospective study
Authors' conclusion
In outpatients with T2DM, higher baseline hepcidin concentrations were strongly associated with an increased long-term risk of overall mortality or nonfatal cardiovascular events, even after adjustment for established cardiovascular risk factors, plasma ferritin concentrations, medication use, and other potential confounders.
Study context
- Population
- Outpatients with established T2D (45.5% women, mean age 69 ± 10 years; BMI 28.7 ± 4.7 kg/m²; median diabetes duration 11 years)42 with primary outcome
- Participants
- 213 outpatients
- Exposure
- 3rd vs 1st and 2nd baseline hepcidin tertiles combined
- Outcome
- Composite of:
- All-cause mortality
- Incident nonfatal cardiovascular events (MI, permanent AF, ischemic stroke, or new hospitalization for HF)
- Follow-up
- Median 55.6 months
Main finding
As reported in the abstract
Primary composite outcome
3rd tertile vs 1st and 2nd tertileEstimate (95% CI)P value
Primary composite outcome
unadjusted HR 2.32(1.27–4.26)
P = 0.007Adjusted for age, sex, adiposity, smoking, hypertension, statin, antiplatelet use, hs-CRP and ferritin
adjusted HR 2.53(1.27–5.03)
P = 0.008Observational data: associations, not effects.
Original publication
Elevated plasma hepcidin concentrations are associated with an increased risk of mortality and nonfatal cardiovascular events in patients with type 2 diabetes: a prospective study. Cardiovasc Diabetol. Published 17 August 2024. doi:10.
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