Combined risk estimates of diabetes and coronary angiography-derived index of microcirculatory resistance in patients with non-ST elevation myocardial infarction
Authors' conclusion
In patients with NSTEMI, the combination of DM and CMD is an independent predictor of cardiac death or readmission for heart failure. Angio-IMR could be used as an additional evaluation tool for the management of NSTEMI patients with DM.
Study context
- Population
- Patients with NSTEMI who underwent successful percutaneous coronary intervention (PCI), three centers
- Participants
- 2,212 patients
- Exposure
- Diabetes mellitus (DM) vs non-DM, and combined DM and coronary microvascular dysfunction (CMD)
- Outcome
- Composite of:
- Cardiac death
- Readmission for HF
- Follow-up
- 2 years
Methodological detailsmulticentre (three centers)
- Multicentre (three centers)
Main finding
As reported in the abstract
Cardiac death or readmission for HF
P < 0.001
- DM plus CMD: highest cumulative incidence of cardiac death or readmission for HF at 2 years
- 24.0%, P < 0.001
- DM plus CMD as most powerful independent predictor (aHR)
- 7.894 [95% CI, 4.251-14.659], p < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | DM | Non-DM | P value |
|---|---|---|---|
| Post-PCI angio-IMRDid not significantly differ | 20.13 (range 17.91–22.70) | 20.19 (range 18.14–22.77) | P = 0.530 |
Original publication
Combined risk estimates of diabetes and coronary angiography-derived index of microcirculatory resistance in patients with non-ST elevation myocardial infarction. Cardiovasc Diabetol. Published 16 August 2024. doi:10.
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