Elevated 1-hour Post Load Glucose as a Predictor for Telomere Attrition: A Study Based on a Chinese Community Population
Authors' conclusion
1h-PG outperforms other glycemic parameters in predicting telomere attrition and can be a valuable marker for early aging detection.
Study context
- Population
- Chinese community cohort; nondiabetic and diabetic populations analysed separatelycross-sectional study
- Participants
- 715 participants
- Exposure
- 1h-PG vs other glycemic parameters for identifying and predicting telomere attrition
- Outcome
- Association of glycemic parameters with relative telomere length and telomere attrition
Methodological detailscommunity-based, 7-year follow-up
- Community-based
- 7-year follow-up
Main finding
As reported in the abstract
Nondiabetic: β (95% CI −0.068 to −0.007), P = .017
−.106
Nondiabetic: OR (95% CI 1.069 to 1.239), P = .005
1.151
Diabetic: β (95% CI −0.032 to −0.007), P = .002
−.222
Diabetic: OR (95% CI 1.041 to 1.258), P = .035
1.144
Observational data: associations, not effects.
Further findings
Association of 1h-PG with telomere shortening, nondiabetic (longitudinal; 437 recruited, 112 followed) · 7-years follow-up
- β (95% CI −0.276 to −0.032), P = .016
- −.314
- OR (95% CI 1.158 to 6.274), P = .021
- 2.659
Area under the receiver operating characteristic (AUROC) for identifying and predicting telomere attrition
- 1h-PG outperformed other glycemic parameters in identifying and predicting telomere attrition
Reclassification by 1h-PG
- NGT and prediabetic individuals with elevated 1h-PG had telomere lengths comparable to prediabetic and diabetic populations, respectively
Original publication
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