Graded association of muscle strength with all‐cause and cause‐specific mortality in older adults with diabetes: Prospective cohort study across 28 countries
Authors' conclusion
Muscle strength is gradually and inversely associated with all-cause and cause-specific mortality risk in older adults with diabetes. As muscle strength is highly adaptable to resistance training at all ages, the present findings highlight the importance of improving muscle strength in older adults with diabetes.
Study context
- Population
- Adults aged ≥50 years with diabetes (diagnosis ever and current diabetes medication), Survey of Health, Ageing and Retirement in Europe (SHARE) study, 28 countries; mean age 68.2 (SD 9.2) years
- Participants
- 16,149 adults
- Exposure
- Levels of handgrip muscle strength vs median
- Outcome
- All-cause mortality
- Follow-up
- Mean 5.9 years (SD 3.8)
Methodological detailsmultinational (28 countries), time-varying Cox regression with restricted cubic splines
- Multinational (28 countries)
- Time-varying Cox regression with restricted cubic splines
Main finding
As reported in the abstract
Each group vs medianHazard ratio (95% CI)
10th percentile
1.65(1.53–1.79)
90th percentile
0.55(0.49–0.63)
- Deaths
- 2754 (17%)
Observational data: associations, not effects.
Further findings
Cause-specific mortality (cardiovascular disease (CVD), respiratory disease, severe infectious disease, digestive system disease, cancer)
- Somewhat similar pattern, with varying strength of associations
Original publication
Graded association of muscle strength with all‐cause and cause‐specific mortality in older adults with diabetes: Prospective cohort study across 28 countries. Diabetes Obes Metab. Published 23 October 2024. doi:10.
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