Eight‐hour time‐restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial
Authors' conclusion
Consuming food within an 8-hour time-restricted period does not lower daily MyoPS rates when compared with an isoenergetic diet consumed over 12 hours. Future research should investigate whether these results translate to free-living TRE.
Study context
- Population
- Healthy males with overweight/obesity (age 46 ± 5 years; BMI 30 ± 2 kg/m²)completed
- Participants
- 18 males
- Comparison
- 8-h time-restricted eating (TRE) vs extended eating control (CON), isoenergetic diet, 10 days
- Primary endpoint
- Daily integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates (deuterated water)
- Follow-up
- 10 days
Methodological detailsexploratory, parallel, 3-day lead-in diet
- Exploratory
- Parallel
- 3-day lead-in diet
Primary result
As reported in the abstract
Daily integrated MyoPS rate
P = 0.82
Further findings
| Outcome | TRE | CON | P value |
|---|---|---|---|
| CGM 24-hour total AUC changeReduced following TRE | −578 ± 271 mmol/L × 24 hours | 12 ± 272 mmol/L × 24 hours | P = 0.001 |
| Total body mass changeNo differences between groups | −1.6 ± 0.9 kg | −1.1 ± 0.7 kg | P = 0.22 |
| Lean mass change (DXA)Lean mass loss greater with TRE | −1.0 ± 0.7 kg | −0.2 ± 0.5 kg | P = 0.01 |
- Total body mass change — Total body mass declined
- p < 0.001
Original publication
Eight‐hour time‐restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial. Obesity (Silver Spring). Published 22 December 2022. doi:10.
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